Genotropin (Somatropin)

Description

Product Information

Genotropin is a brand-name prescription medication containing somatropin, a recombinant form of human growth hormone (HGH) produced via recombinant DNA technology in Escherichia coli bacteria. It is bioidentical to the naturally occurring 191-amino-acid polypeptide hormone secreted by the pituitary gland. http://google.com

It is primarily indicated for:

• Growth failure in children due to growth hormone deficiency (GHD).
• Prader-Willi syndrome (PWS).
• Small for gestational age (SGA) without catch-up growth.
• Turner syndrome (TS).
• Idiopathic short stature (ISS).
• Replacement therapy in adults with GHD (childhood- or adult-onset).

Genotropin promotes linear growth in children, improves body composition (increases lean mass, reduces fat), supports bone density, and aids metabolic functions in deficient patients.

Chemical Structure

Somatropin in Genotropin consists of 191 amino acid residues with a molecular weight of approximately 22,124 daltons. It features two disulfide bonds and an identical sequence to endogenous pituitary human growth hormone.

CAS Number: 12629-01-5 (for somatropin/human growth hormone).

Chemical Formula: C₉₉₀H₁₅₂₉N₂₆₃O₂₉₉S₇ (approximate for the full protein sequence).

H3: Technical Details

• Form: Lyophilized (freeze-dried) white powder in two-chamber cartridges for reconstitution.
• Strengths: 5 mg, 12 mg pens; Miniquick single-dose 0.2–2.0 mg.
• Reconstitution: Mixes with diluent (often containing metacresol as preservative in multi-dose). Post-reconstitution concentration: ~5 mg/mL or 12 mg/mL.
• Administration: Subcutaneous injection, typically daily.
• Storage: Refrigerate unreconstituted (2–8°C); follow specific guidelines for in-use pens.
• Half-life: ~3 hours subcutaneously in GHD patients.
• Production: Recombinant DNA in modified E. coli; highly purified.

H3: Packaging Information

Genotropin is supplied in convenient delivery systems:

• Genotropin Pen: Reusable multi-dose device with 5 mg (green) or 12 mg (purple) two-chamber cartridges.
• Genotropin Miniquick: Single-dose, pre-filled, preservative-free options for precise dosing.
• Contents: Powder in one chamber, diluent in the other; mixes by twisting the pen

Common Research Applications Include

• Studying growth hormone effects on linear growth, bone metabolism, and body composition.
• Investigating metabolic impacts (lipid, carbohydrate, protein metabolism).
• Pediatric endocrinology research on syndromes like PWS, TS, SGA.
• Adult GHD replacement therapy outcomes.
• Pharmacokinetics and bioavailability studies.

Note: Primarily for clinical/medical research; off-label or performance use is not approved.

Precautions

• Contraindications: Active malignancy, diabetic retinopathy, hypersensitivity, acute critical illness, closed epiphyses in children, severe obesity/respiratory issues in PWS.
• Monitor for intracranial hypertension, glucose intolerance/diabetes, hypothyroidism, scoliosis progression, slipped capital femoral epiphysis.
• Common side effects: Injection site reactions, headache, joint/muscle pain, edema, carpal tunnel (adults).
• Regular monitoring of growth, IGF-1, glucose, thyroid, etc., is essential.
• Pregnancy/breastfeeding: Consult physician; limited data.

Link to buy Genotropin? http://slimpept.com